

Awangarda Foundation
Diabetes
Diabetes Insipidus vs. Mellitus
Diabetes Insipidus
Diabetes insipidus (DI), also called arginine vasopressin deficiency, is characterized by increased urine production. There are several classifications including: central DI (not enough vasopressin is produced), nephrogenic DI (body makes vasopressin but kidneys become resistant), dipsogenic DI (problem with hypothalamus which causes you to feel thirstier and drink more water), and gestational DI (the placenta makes too much of an enzyme that breaks down vasopressin prematurely).
Diabetes Mellitus
Diabetes mellitus (DM) is characterized by abnormal blood glucose levels. There are two main types of DM: DM type-1 and DM type-2. DM type-1 is caused by a mutation of the DMPK gene and is associated with ketosis when blood glucose levels become abnormally elevated. In type-1 DM, the beta cells of the pancreas no longer make insulin. DM type-2 is caused by a mutation in the CNBP gene and is typically associated with proximal muscle weakness. In type-2 DM, the pancreas may still make insulin, however cells become resistant to it.
